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ENRHES

Review of health & environmental safety of nanoparticles

FP7_200ENRHES (Engineered Nanoparticles - Review of Health and Environmental Safety) was a 12 month project, which completed in 2009. It was co-ordinated by Professor Vicki Stone of Heriot Watt University (formerly Edinburgh Napier University) UK.

The primary aim of ENRHES was to perform a comprehensive and critical scientific review of the health and environmental safety of fullerenes, carbon nanotubes (CNTs), metal and metal oxide nanomaterials.

The review considers sources, pathways of exposure, the health and environmental outcomes of concern, in the context illustrating the state-of-the-art in the field and informing the regulation of the potential risks of engineered nanoparticles. This provides an overview of the current state of knowledge concerning exposure to nanoparticles and ongoing work in the area. Prioritised recommendations in each of the themes tackled have been developed and set in the context of informing policy makers. The results and conclusions drawn through the review have been disseminated to stakeholders concerned with the potential risks to the environment and human health from nanomaterials via high impact routes, for example through cooperation with NanoImpactNet.

ENRHES brought together leading experts with established track-records in experimental science, engagement with industry and regulators, and in conducting reviews. IOM acted as scientific lead for this project.

The final ENRHES Review is available to download here.

In addition, the outputs of ENRHES led to a number of publications, which are listed below:

Aschberger, K., Micheletti, C., Sokull-Klüttgen, B., Christensen, F.M. 2011, "Analysis of currently available data for characterising the risk of engineered nanomaterials to the environment and human health – Lessons learned from four case studies," Environment International, vol. 37, no. 6, pp. 1143-56.
View abstract.

Aschberger, K., Johnston, H.J., Stone, V., Aitken, R.J., Tran, C.L., Hankin, S.M., Peters, S.A.K., Christensen, F.M. 2010, "Review of carbon nanotubes toxicity and exposure – assessment of the feasibility and challenges for human health risk assessment based on open literature," Crit Rev Toxicol, vol. 40, no.9, pp. 759-790.
View abstract.

Christensen, F.M., Johnston, H.J., Stone, V., Aitken, R.J., Hankin, S., Peters, S., Aschberger, K. 2010, "Nano–silver - feasibility and challenges for human health risk assessment based on open literature," Nanotoxicology, vol. 4, no. 3, pp. 284–295.
View abstract.

Aschberger, K., Johnston, H.J., Stone, V., Aitken, R.J., Tran, C.L., Hankin, S.M., Peters, S.A.K., Christensen, F.M. 2010, “Review of fullerene toxicity and exposure – a human health risk assessment appraisal based on open literature,” Regul Toxicol Pharmacol 58(3):455-473.
View abstract.

Christensen, F.M., Johnston, H.J., Stone, V., Aitken, R.J., Hankin, S., Peters, S., Aschberger, K. 2010, “Nano titanium–dioxide - feasibility and challenges for human health risk assessment based on open literature,” Nanotoxicology, vol. 5, no. 2, pp. 110-24.
View abstract.

Johnston, H.J., Hutchison, G.R., Christensen, F.M., Aschberger, K., Stone, V. 2010, “The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity,” Toxicol Sci, vol. 114, no. 2, pp. 162-182.
View abstract.

Johnston, H.J., Hutchison, G.R., Christensen, F.M., Peters, S., Hankin, S., Aschberger, K., Stone, V. 2009, “A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes; the contribution of physicochemical characteristics,” Nanotoxicology, vol. 4, no. 2, pp. 207-246.
View abstract.

Johnston, H.J., Hutchison, G.R., Christensen, F.M., Peters, S., Hankin, S., Stone, V. 2009, “Identification of the mechanisms that drive the toxicity of TiO2 particulates; the contribution of physicochemical characteristics,” Part Fibre Toxicol, vol. 6, no. 33.
View abstract.

Johnston, H.J., Hutchison, G.R., Christensen, F.M., Peters, S., Hankin, S., Stone, V. 2010, “A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity,” Crit Rev Toxicol, vol. 40, no. 4, pp. 328-46.
View abstract.

Did you know?

< 5 is the number of layers in few-layer graphene (FLG).