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ISO publishes standard for the detection of reactive oxygen species generated by metal oxide nanomaterials

Date: 02/6/2017

The International Organization for Standardization (ISO) has published a new standard (ISO/TS 18827:2017) in its Nanotechnologies series entitled “Electron spin resonance (ESR) as a method for measuring reactive oxygen species (ROS) generated by metal oxide nanomaterials”.

Recently, the use of metal or metal oxide-based nanomaterials has dramatically increased in biomedical and industrial applications. However, the scientific basis for the cytotoxicity and genotoxicity of most manufactured nanomaterials are not fully understood. An important mechanism of nanotoxicity is the generation of reactive oxygen species (ROS). The ability to generate ROS is one main source of toxicity of metal oxide nanomaterials. Overproduction of ROS can induce oxidative stress, resulting in cells failing to maintain normal physiological redox-regulated functions. This in turn may lead to DNA damage, unregulated cell signalling, change in cell motility, cytotoxicity, apoptosis and cancer initiation.

ISO/TS 18827:2017 provides a procedure for the detection of ROS (OH, O2-, 1O2) generated by metal oxide nanomaterials in aqueous solution with a reactive oxygen species-specific spin trapping agent using ESR, but excludes ESR procedures that do not use a spin trapping agent.

A preview of the standard is available via ISO’s Online Browsing Platform.

Source: ISO

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100 nm is the size below which the EU recommendation of the definition of nanomaterials applies.