The unique properties of manufactured nanomaterials have raised the question as to whether the current OECD Test Guidelines are adequate to appropriately address their characterisation and the assessment of their toxicological properties.
The purpose of this guidance document, published for the Organisation of Economic Cooperation and Development (OECD), is primarily to assist sponsors as they conduct testing in support of the OECD Sponsorship Programme for the Testing of Manufactured Nanomaterials as well as other users involved in the testing of manufactured nanomaterials. It therefore focuses on the kinds of tests that address the endpoints and the types of nanomaterials being tested under the sponsorship programme. Nevertheless, the WPMN hopes that this guidance will also be of use to the scientific community at large, in particular to those investigators conducting tests to advance understanding of the environmental, health, and safety implications of manufactured nanomaterials.
This guidance includes common issues as well as specific considerations on sample preparation and dosimetry for the safety testing of manufactured nanomaterials, covering physico-chemical characterisation and (eco)toxicology studies.