SAFENANO's Top Toxicology Papers
The following reading list details what we consider to be some of the most informative papers available relating to toxicity of nanomaterials.
Our selections have been categorised to allow you access to those papers of most interest to your area. These will be updated regularly to ensure that we make the most up to date information available to our readers.
Further reports of relevance to this area in combination with other topics may be included in the Cross-cutting Reports list.
Kroll, A., Pillukat, M.H., Hahn, D., Schnekenburger, J. 2009, "Current in vitro methods in nanoparticle risk assessment: Limitations and challenges", European Journal of Pharmaceutics and Biopharmaceutics, vol.72, no.2, pp. 370-377.
Rushton, E.K., Jiang, J., Leonard, S.S., Eberly, S., Castranova, V., Biswas, P., Elder, A., Han, X., Gelein, R., Finkelsteina, J., Oberdörster, G. 2010, "Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics", Journal of Toxicology and Environmental Health, Part A, vol. 73 pp. 445-461.
Oller, A.R., Oberdörster, G. 2010, "Incorporation of particle size differences between animal studies and human workplace aerosols for deriving exposure limit values", Regul ,Toxicol Pharmacol, Vol. 57, no.2-3, pp. 181-194.
Oberdörster, G. 2010, "Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology", J Intern Med, vol. 26, no.1, pp. 89-105.
Meng, H., Xia, T., George, S., Nel, A.E. 2009, "A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials", Acs Nano, vol. 3, no. 7, pp. 1620-1627.
Semmler-Behnke, M., Kreyling, W.G., Lipka, J., Fertsch, S., Wenk, A., Takenaka, S., Schmid, G. and Brandau, W. 2008, "Biodistribution of 1.4- and 18-nm Gold Particles in Rats", Small, vol. 4, no. 12, pp. 2108-2111.
Kreyling, W. Geiser, M. 2010, "Deposition and biokinetics of inhaled nanoparticles", Particle & Fibre Toxicology, vol.7, no. 2.
Kreyling,W. G.;Semmler-Behnke,M., Seitz,J., Scymczak,W., Wenk,A., Mayer,P., Takenaka,S., Oberdorster,G. 2009, "Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs", Inhalation toxicology, vol. 21 Suppl1, pp. 55-60.
Ellinger-Ziegelbauer,H.;Pauluhn,J. 2009, "Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period", Toxicology, vol.266, no.1-3, pp. 16-29.
Ma-Hock, L., Treumann, S., Strauss, V., Gamer, A.O., Wiench, K., van Ravenzwaay, B., Landsiedel, R. 2009, "Short-term inhalation tests with eight nano-materials in rats", Naunyn-Schmiedebergs Archives of Pharmacology, vol. 379, pp. 331.
Kishore, A.S., Surekha, P., Murthy, P.B. 2009, "Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods", Toxicology letters, vol.191, no. 2-3, pp. 268-274.
Ma-Hock, L., Treumann, S., Strauss, V., Brill, S., Luizi, F., Mertler, M., Wiench, K., Gamer, A.O., van Ravenzwaay, B., Landsiedel, R. 2009, "Inhalation toxicity of multi-walled carbon nanotubes in rats exposed for 3 months", Toxicol Sci, vol.112, pp. 273-275.
Pauluhn, J. 2010, "Multi-walled carbon nanotubes (Baytubes(R)): Approach for derivation of occupational exposure limit", Regulatory toxicology and pharmacology, vol. 57, no. 1, pp. 78-89.
McAuliffe, M.E., Perry, M.J. 2007, "Are nanoparticles potential male reproductive toxicants? - A literature review", Nanotoxicology, vol.1, no.3, pp. 204-210.
Link to abstract
Yoshida, S., Hiyoshi, K., Ichinose, T., Takano, H., Oshio, S., Sugawara, I., Takeda, K. and Shibamoto, T. 2008, "Effect of nanoparticles on the male reproductive system of mice", International Journal of Andrology, vol. 32, no. 4, pp. 337-42.
Inoue, K.I., Yanagisawa, R., Koike, E., Nishikawa, M., Takano, H. 2010, "Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress", Free radical biology & medicine, vol. 48, no. 7, pp. 924-934.
Landsiedel, R., Kappb, M.D., Schulz, M., Wiench, K. and Oesch, F. 2009, "Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations- Many questions, some answers", Mutation Research/Reviews in Mutation Research, vol. 681, no. 2, pp. 241-258.
Becker, H., Herzberg, F., Schulte, A., Kolossa-Gehring, M. 2010, "The carcinogenic potential of nanomaterials, their release from products and options for regulating them", Int J Hyg Environ Health [epub ahead of print].
Duffin, R., Mills, N.L. and Donaldson, K. 2007, "Nanoparticles - A thoracic Toxicology Perspective", Yonsei Medical Journal, vol. 48, no. 4, pp. 561-572.
Larese, F.F., D'Agostin, F., Crosera, M., Adami, G., Renzi, N., Bovenzi, M., Maina, G. 2009, "Human skin penetration of silver nanoparticles through intact and damaged skin", Toxicology vol. 255, no. 1-2, pp. 33-37.
Osmond, M.J. and Mccall, M.J. 2010, "Zinc oxide nanoparticles in modern sunscreens: An analysis of potential exposure and hazard", Nanotoxicology, vol. 4, no. 1, pp. 15-41.
Murphy, F.A., Poland C.A., Duffin, R., Al-Jamal, K.T., Ali-Boucetta, H.A., Nunes, A., Byrne, F., Prina-Mello, A., Volkov, Y., Li, S., Mather, S.J., Bianco, A., Prato, M., MacNee, W., Wallace, W.A., Kostarelos, K., Donaldson, K. 2011, "Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Pareital Pleura, Am. Journal of Pathology, vol. 178, no. 6, pp2587-2600
Link to abstract
Donaldson, K. Murphy, F.A., Duffin, R., Poland, C.A. 2010, "Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma", Part Fibre Toxicol, vol. 22, pp. 7-5.
Poland, C.A., Duffin, R., Kinloch, I.A., Maynard, A., Wallace, W.A.H., Seaton, A., Stone, V., Brown, S., MacNee, W. and Donaldson, K. 2008, "Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study", Nature Nanotechnol, vol. 3, no. 7, pp. 423-428.
Porter, D.W., Hubbs, A.F., Mercer, R.R., Wu, N., Wolfarth, M.G., Sriram, K., Leonard, S., Battelli, L., Schwegler-Berry, D., Friend, S., Andrew, M., Chen, B.T., Tsuruoka, S., Endo, M., Castranova, V. 2010, "Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes", Toxicology, vol. 269, no. 2-3, pp. 136-147.
Mercer, R.R., Hubbs, A.F., Scabilloni, J.F., Wang, L., Battelli, L.A., Schwegler-Berry, D., Castranova, V., Porter, D.W. 2010, "Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes", Part Fibre Toxicol, vol.7, pp. 28.
Oberdörster, G., Elder, A., Rinderknecht, A. 2009, "Nanoparticles and the brain: cause for concern?", J Nanosci Nanotechnol, vol. 9, no. 8, pp. 4996-5007.
Shvedova, A.A., Kisin, E., Murray, A. R., Johnson, V. J., Gorelik, O., Arepalli, S., Hubbs, A. F., Mercer, R. R., Keohavong, P., Sussman, N., Jin, J., Yin, J., Stone, S., Chen, B. T., Deye, G., Maynard, A., Castranova, V., Baron, P. A., Kagan, V. E. 2008, "Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 295, no. 4, pp. L552-L565.
Cedervall, T., Lynch, I., Lindman, S., Berggárd, T, Thulin, E, Nilsson, H., Linse, S., Dawson, KA. 2007, "Understanding the nanoparticle protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles", PNAS, vol. 104, pp. 2050 -2055.
Duffin, R., Tran, L., Brown, D., Stone, V., Donaldson, K. 2007, "Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity", Inhal Toxicol, vol. 19, no. 10, pp. 849-855.
Johnston, H.J., Hutchison, G.R., Christensen, F.M., Peters, S., Hankin, S. Aschberger, K., Stone, V. 2010, "A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: the contribution of physcio-chemical charcteristics", Nanotoxicology, vol. 4, no. 2, pp. 207-246.
Johnston, H.J., Hutchison, G.R., Christensen, F.M., Peters, S., Hankin, S. Aschberger, K., Stone, V. 2010, "A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity", Crit rev Toxicol, vol. 40, no. 4, pp. 328-346.
Simeonova, P.P., Erdely, A. 2009, "Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers", Inhalation toxicology, vol. 21 Suppl 1, pp. 68-73.
Limbach, L.K., Grass, R.N. & Stark, W.J. 2009, "Physico-Chemical Differences Between Particle- and Molecule-Derived Toxicity: Can We Make Inherently Safe Nanoparticles?", Chimia, vol. 63, no. 1-2, pp. 38-43.